反应详情

温度

140 °C

1-Octyne-3-ol (1.136 g, 9 mmol), aniline (0.559 g, 6 mmol), Ru3(CO)12 (16.0 mg, 0.025 mmol) and aniline hydrochloride (0.130 g, 1.0 mmol) were placed in a 10 ml round-bottomed flask, and the mixture was stirred at 140° C. for 9 hours. After cooling, diethyl ether (3 mL) was added, and the organic layer was washed twice with 1 M hydrochloric acid (2 mL) and once with water (2 mL). The organic layer was dried over sodium sulfate, and the solvent was distilled away, whereby an 11:1 mixture of 3-methyl-2-pentyl indole and 2-methyl-3-pentyl indole (1.262 g; 6.3 mmol; yield, 95%; purity, about 95% or more) was obtained.

1. temperatureAfter cooling
2. washthe organic layer was washed twice with 1 M hydrochloric acid (2 mL) and once with water (2 mL)
3. dry with materialThe organic layer was dried over sodium sulfate
4. distillationthe solvent was distilled away
5. additionwhereby an 11:1 mixture of 3-methyl-2-pentyl indole