HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-Hydroxyacetophenone → 1-[4-(3-Chloropropoxy)phenyl]ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propanoyl chloride, 3-bromo- | HCID 84944 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-[4-(3-Chloropropoxy)phenyl]ethanone | HCID 12685613 | — |
Reaction Steps
A solution of 4′-hydroxyacetophenone (20 mmol, 2.72 g), 3-bromopropionyl chloride (21 mmol, 2.07 mL) and potassium carbonate (4.14 g, 30.0 mmol) in acetone (50 mL) was heated at reflux for overnight. The salt was filtered off. The solvent was evaporated. After drying in vacuo, the title compound (4.24 g) was collected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872834B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-79aed0dff7c641c4ac666a0afe501f33 |
| Source note | uspto-grants-2005_03 |