HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-(3-Chloropropoxy)-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propanoyl chloride, 3-bromo- | HCID 84944 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-(3-Chloropropoxy)-benzaldehyde | HCID 3551479 | 75.5% |
Reaction Steps
A solution of 4-hydroxybenzaldehyde (100 mmol, 12.2 g), 3-bromopropionyl chloride (101 mmol, 20 mL) and potasium carbonate (20.7 g, 150 mmol) in acetone (250 mL) was heated at reflux for overnight. The salt was filtered off. The solvent was evaporated. Reduced pressure distillation provided the title compound (15 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872834B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-208e391071a845ec9c512e97d87f6b99 |
| Source note | uspto-grants-2005_03 |