Water → HCID 22507779, compound

Participants

Reaction Conditions

Reaction Steps

To LDA (2M in THF, 15 mL) in THF (100 mL) at −78° C., TMSCHN2 (2M in hexanes, 15 mL) was added dropwisely. Ten minutes later, 4-(3-chloropropoxy)benzaldehyde (0.025 mol, 4.97 g) in THF (60 mL) was added. After 1 h stirring at −78° C., the mixture was warmed up and refluxed for 3 h. Water (250 mL) was added and extracted by EtOAc (2×200 mL). After being dried over Na2SO4 and concentration, the title compound (4.8 g) was obtained.

Provenance & Evidence