HCID 22925713, compound → HCID 178426060, compound

Participants

Reaction Steps

1 g of 4-(4′-(4″-hydroxyphenyl)cyclohexyl)-2-methyl-1-hydroxybenzene obtained in Example 1 was dissolved in 10 g of methanol at room temperature. The solution was injected into a preparative high performance liquid chromatography to carry out separation of cis- and trans-isomers (solvent: 60% aqueous solution of methanol; time: 40 minutes). As a result, about 50 mg of 4-(trans-4′-(4″-hydroxyphenyl)cyclohexyl)-2-methyl-1-hydroxybenzene was obtained as white crystals with a retention time of 17.6 minutes. It was found to have a purity of 99% and a melting point of 214° C. (DTA method). Furthermore, about 100 mg of 4-(cis-4′-(4″-hydroxyphenyl)cyclohexyl)-2-methyl-1-hydroxybenzene was obtained as pale yellow oily substance with a retention time of 28.2 minutes. It was found to have a purity of 99%.

Provenance & Evidence