HCID 22508141, compound → HCID 22925721, compound

Participants

Reaction Steps

26.6 g (0.081 mol) of 1-(3-t-butyl-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-cyclohexene obtained in Example 4 of Example A, 266 g of isopropyl alcohol and 5.5 g of Raney nickel catalyst were placed in a reaction vessel (1L capacity autoclave), and then in the same manner as in Example 3, 26.6 g of 4-(4′-(4″-hydroxyphenyl)-cyclohexyl)-2-t-butyl-1-hydroxybenzene was obtained as white crystals having a purity of 97.9% (high performance liquid chromatography). The yield was found to be 99.2 mol % based on the 1-(3-t-butyl-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-cyclohexene. The selectivity of trans-/cis-isomers of 4-(4′-(4″-hydroxyphenyl)cyclohexyl)-2-t-butyl-1-hydroxybenzene was found to be 64/36 (high performance liquid chromatography).

Provenance & Evidence