HCID 22508144, compound → HCID 22508118, compound

Participants

Reaction Steps

19.6 g (0.063 mol) of 1-(3,5-dimethyl-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-cyclohexene obtained in Example 5 of Example A, 300 g of isopropyl alcohol and 5.2 g of Raney nickel catalyst were placed in a reaction vessel (1L capacity autoclave), and then in the same manner as in Example 3, 18.6 g of 4-(4′-(4″-hydroxyphenyl)-cyclohexyl)-2,6-dimethyl-1-hydroxybenzene) was obtained as white crystals having a purity of 92.7% (high performance liquid chromatography). The yield was found to be 92.0 mol % based on the 1-(3,5-dimethyl-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-1-cyclohexene used. The selectivity of trans-/cis-isomers of 4-(4′-(4″-hydroxyphenyl)cyclohexyl)-2,6-dimethyl-1-hydroxybenzene was found to be 69/31 (high performance liquid chromatography).

Provenance & Evidence