HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azetidine → (+)-2-Azetidin-1-yl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azetidine | HCID 10422 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 22507693 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (+)-2-Azetidin-1-yl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 11487132 | — |
Reaction Steps
From (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide with cesium carbonate and azetidine. [α]D20=+25.5° (c=0.26, CHCl3), ES-MS m/e (%): 427 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-53e66b7a415747fea1301a20b9abbf56 |
| Source note | uspto-grants-2005_03 |