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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985810Generated: October 31, 2026

Diethylamine → (+)-2-Diethylaminomethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide

https://huagongshe.com/reaction/985810

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethylamineHCID 8021—
ReactantCesium carbonateHCID 10796—
Reactant(+)-2-chloromethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamideHCID 22507718—
SolventChloroformHCID 6212—
Product(+)-2-Diethylaminomethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamideHCID 22507749—

Reaction Steps

From (+)-2-chloromethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide with cesium carbonate and diethylamine. [α]D20=+48.9° (c=1.02, CHCl3), ES-MS m/e (%): 457 (M+H+, 100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06872833B2
Source datasetuspto-grants-2005_03
ORD IDord-ddcf89b90e304643a34bf1af3935db7e
Source noteuspto-grants-2005_03