HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → (+)-4-Hydroxy-piperidine-1-carboxylic acid (7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | (+)-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester | HCID 20769454 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (+)-4-Hydroxy-piperidine-1-carboxylic acid (7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-amide | HCID 86594652 | — |
Reaction Steps
From (+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester with 4-hydroxypiperidine and pyridine in chloroform. [α]D20=+29.4° (c=1.01, CHCl3), ES-MS m/e (%): 394 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-00a7f720480d4fba89968db6c388d9e4 |
| Source note | uspto-grants-2005_03 |