HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-methoxymethyl-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | (+)-2-chloromethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 22507718 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-methoxymethyl-isonicotinamide | HCID 22507735 | — |
Reaction Steps
From (+)-2-chloromethyl-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide with sodium methylate in methanol. [α]D20=+65.1° (c=0.55, CHCl3), ES-MS m/e (%): 416 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-244a5efa38b24b3fa8145ea04db6fd45 |
| Source note | uspto-grants-2005_03 |