HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-(3-methoxy-azetidin-1-yl)-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Methoxyazetidine hydrochloride | HCID 22242858 | — |
| Reactant | (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 22507693 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-(3-methoxy-azetidin-1-yl)-isonicotinamide | HCID 11487896 | — |
Reaction Steps
From (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide with cesium carbonate and 3-methoxy-azetidine hydrochloride in DMF. [α]D20=+42.5° (c=0.44, CHCl3), ES-MS m/e (%): 457 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-33dabb80d3a34c53a3e4bbe69a97eebe |
| Source note | uspto-grants-2005_03 |