HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxybenzoic Acid → (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-3-methoxy-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxybenzoic Acid | HCID 11461 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | (+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine | HCID 22507697 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-3-methoxy-benzamide | HCID 11246578 | — |
Reaction Steps
From 3-methoxybenzoic acid, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+24.3° (c=0.79, CHCl3), ES-MS m/e (%): 401 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-1c13b6e5e2844421b369b4108f8d95b5 |
| Source note | uspto-grants-2005_03 |