HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → (+)-2-Cyclopropylmethoxy-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide sodium hydride | HCID 23670120 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (+)-2-Cyclopropylmethoxy-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide | HCID 22507765 | — |
Reaction Steps
From (+)-2-bromo-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-isonicotinamide sodium hydride and hydroxymethylcyclopropane in dioxane and DMF. [α]D20=+39.2° (c=1.02, CHCl3), ES-MS m/e (%): 442 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-8c8e7fb5b1af4e9aa545d293717e57df |
| Source note | uspto-grants-2005_03 |