Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-pyridin-2-yl-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Pyridineacetic acid, hydrochloride (1:1) | HCID 85317 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | (+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine | HCID 22507697 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (+)-N-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-2-pyridin-2-yl-acetamide | HCID 22507694 | — |
반응 단계
From 2-pyridylacetic acid hydrochloride, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+26.8° (c=0.51, CHCl3), ES-MS m/e (%): 386 (M+H+, 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06872833B2 |
| 출처 데이터셋 | uspto-grants-2005_03 |
| ORD ID | ord-0c610cbead124931a039ece5a621ea7d |
| 출처 메모 | uspto-grants-2005_03 |