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Diisopropylethylamine → (+)-4-Dimethylamino-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-butyramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | 4-(Dimethylamino)butyric acid hydrochloride | HCID 12691640 | — |
| 反応物 | (+)-7-[1,4)Dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine | HCID 22507697 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (+)-4-Dimethylamino-N-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-butyramide | HCID 22507699 | — |
反応手順
From 4-(dimethylamino)butyric acid hydrochloride, HATU and N-ethyldiisopropylamine in THF, then treatment with (+)-7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-ylamine. [α]D20=+24.2° (c=0.53, CHCl3), ES-MS m/e (%): 380 (M+H+, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06872833B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-f95767e42eda44cba0b26524ab4b2b4b |
| 出典メモ | uspto-grants-2005_03 |