Pyridine → HCID 86594658, compound

HRID 985865Notes

Reaction equation

HRID 985865 reaction equation
C1(O[C:8](=[O:27])[NH:9][C:10]2[S:11][C:12]3[C:18]([CH:19]4[CH2:24][O:23][CH2:22][CH2:21][O:20]4)=[CH:17][CH:16]=[C:15]([O:25][CH3:26])[C:13]=3[N:14]=2)C=CC=CC=1.FC(F)(F)C(O)=O.[C@H:35]12[CH2:41][C@H:38]([NH:39][CH2:40]1)[CH2:37][O:36]2.N1C=CC=CC=1>C(Cl)(Cl)Cl>[O:20]1[CH2:21][CH2:22][O:23][CH2:24][CH:19]1[C:18]1[C:12]2[S:11][C:10]([NH:9][C:8]([N:39]3[CH2:40][C@@H:35]4[CH2:41][C@H:38]3[CH2:37][O:36]4)=[O:27])=[N:14][C:13]=2[C:15]([O:25][CH3:26])=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 20769454(+)-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl esterHCID 68824959HCID 68824959, compound

Product 1

HCID 86594658HCID 86594658, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

From (+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester with (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane trifluoroacetate and pyridine in chloroform. [α]D20=−11.9° (c=0.51, CHCl3), ES-MS m/e (%): 392 (M+H+, 100).

Sources & evidence

ORD record
ord-6188c87fbc9145febd42a5841744d99d
Source dataset
uspto-grants-2005_03
Patent number
US06872833B2

Reaction notes

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