HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → (+)-1-Oxa-8-aza-spiro [4.5]decane-8-carboxylic acid (7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (+)-(7-[1,4]Dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester | HCID 20769454 | — |
| Reactant | 1-Oxa-8-azaspiro[4.5]decane, trifluoroacetate (9CI) | HCID 22507707 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (+)-1-Oxa-8-aza-spiro [4.5]decane-8-carboxylic acid (7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-amide | HCID 86594662 | — |
Reaction Steps
From (+)-(7-[1,4]dioxan-2-yl-4-methoxy-benzothiazol-2-yl)-carbamic acid phenyl ester with 1-oxa-8-aza-spiro[4.5]decane trifluoroacetate and N-ethyldiisopropylamine in chloroform. [α]D20=+25.8° (c=1.01, CHCl3), ES-MS m/e (%): 434 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06872833B2 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-a2d64ea76e0b413ab294ac5820037057 |
| Source note | uspto-grants-2005_03 |