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Hydrogen Peroxide → 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Peroxide | HCID 784 | — |
| 反応物 | tert-Butanol | HCID 6386 | — |
| 反応物 | Sodium Sulfite | HCID 24437 | — |
| 反応物 | 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine | HCID 98642 | — |
| 生成物 | 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one | HCID 21885057 | — |
反応手順
Aqueous hydrogen peroxide is added to a mixture of 1-oxyl-2,2,6,6-tetramethylpiperidin-4-one and ferrous chloride in tert-butyl alcohol at 30-60° C. Excess peroxide is decomposed with aqueous sodium sulfite. The organic layer is concentrated and the residue is purified by flash chromatography to afford the desired 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06872832B2 |
| 出典データセット | uspto-grants-2005_03 |
| ORD ID | ord-ef0ebfedf09b4eb49fac9b505e6c7598 |
| 出典メモ | uspto-grants-2005_03 |