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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985931Generated: October 31, 2026

Methyl 4-chloroacetoacetate → Methyl (R)-4-Chloro-3-hydroxybutyrate

https://huagongshe.com/reaction/985931

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-chloroacetoacetateHCID 36240—
SolventChloroformHCID 6212—
ProductMethyl (R)-4-Chloro-3-hydroxybutyrateHCID 10920707—

Reaction Steps

The procedure of example 369 was repeated using methyl-4-chloroacetoacetate as the substrate to afford methyl-4-chloro-3(R)-hydroxybutyrate, [α]D23 +21.15° (c, 4.2 CHCl3).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04710468
Source datasetuspto-grants-1987_12
ORD IDord-55b24647788e4d009f10f39b02477b2a
Source noteuspto-grants-1987_12