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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985932Generated: October 30, 2026

tert-Butyl 4-chloro-3-oxobutyrate → t-butyl-4-chloro-3(R)-hydroxybutyrate

https://huagongshe.com/reaction/985932

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 4-chloro-3-oxobutyrateHCID 2724514—
SolventChloroformHCID 6212—
Productt-butyl-4-chloro-3(R)-hydroxybutyrateHCID 11106250—

Reaction Steps

The procedure of example 369 was repeated using t-butyl-4-chloroacetoacetate as the substrate to give t-butyl-4-chloro-3(R)-hydroxybutyrate, [α]D23 +18.09° (c, 5.1 CHCl3).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04710468
Source datasetuspto-grants-1987_12
ORD IDord-0d3f64c793854208b49b525f022d5a94
Source noteuspto-grants-1987_12