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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985934Generated: October 26, 2026

Ethyl 4-chloroacetoacetate → 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

https://huagongshe.com/reaction/985934

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-chloroacetoacetateHCID 69484—
SolventChloroformHCID 6212—
Product4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-HCID 2734445—

Reaction Steps

The procedure of example 375 was repeated using ethyl-4-chloroacetoacetate as the substrate to afford ethyl-4-chloro-3(R)-hydroxybutyrate, [α]D23 +22.7° (c, 4.7, CHCl3).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04710468
Source datasetuspto-grants-1987_12
ORD IDord-8389e84fd3b24370a02baedee386bff2
Source noteuspto-grants-1987_12