反应详情

Trans-3-[4-(3-Ethoxypropenamido)phenyl]pyridine (1.43 g) was stirred in 98% sulphuric acid (4.0 cm3) for 16 hours. The mixture was added to ice (50 g) and the resulting solution was basified to pH8 with 2.5M sodium hydroxide solution. The mixture was extracted with chloroform:methanol, 9:1 (10×100 cm3), and the combined and dried (MgSO4) extracts were concentrated in vacuo to yield a solid which was recrystallised from isopropanol to afford 6-(3-pyridyl)-2-(1H)-quinolone, m.p. 228°-230° (0.39 g).

1. extractionThe mixture was extracted with chloroform
2. dry with materialdried (MgSO4) extracts
3. concentrationwere concentrated in vacuo
4. customto yield a solid which
5. customwas recrystallised from isopropanol