反应详情

A mixture of 6-bromo-2-[1H]-quinolone (2.90 g) and trimethyloxoniumtetrafluoroborate (2.10 g) was stirred in dichloromethane (50 cm3) for 48 hours under nitrogen. Aqueous 10% sodium hydroxide (20 cm3) was added and the aqueous phase was extracted with dichloromethane (2×40 cm3). The dried (MgSO4) extracts were evaporated and the residue was crystallised from petroleum ether (b.p. 60°-80°) to yield 2-methoxy-6-bromoquinoline, m.p. 90°-94°, (2.16 g).

1. extractionthe aqueous phase was extracted with dichloromethane (2×40 cm3)
2. dry with materialThe dried (MgSO4) extracts
3. customwere evaporated
4. customthe residue was crystallised from petroleum ether (b.p. 60°-80°)