Pyridazine → HCID 14220977, compound

HRID 986003Notes

Reaction equation

HRID 986003 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][N:2]=1.[CH3:7][O:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([Li])[CH:15]=2)[N:10]=1.COC1C=CC2C(=CC=C(C3C=CN=NC=3)C=2)N=1>>[CH3:7][O:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:6]3[N:1]=[N:2][CH:3]=[CH:4][CH:5]=3)[CH:15]=2)[N:10]=1

Participants

4

Reactant 3

HCID 9259PyridazineHCID 14220978HCID 14220978, compoundHCID 178506656HCID 178506656, compound

Product 1

HCID 14220977HCID 14220977, compound

Procedure

The following compounds were prepared similarly to the previous Preparation using pyridazine and 2-methoxy-6-lithioquinoline as starting materials. In this case a mixture of 2-methoxy-6-(4-pyridazinyl)quinoline and 2-methoxy-6-(3-pyridazinyl)quinoline was formed which was separated by chromatography on silica (Merck "MK. 60.9385") eluting with ethyl acetate.

Workup

  1. customThe following compounds were prepared similarly to the previous Preparation

Sources & evidence

ORD record
ord-d514ef50a8b44b8e8af4e7d1a50d258d
Source dataset
uspto-grants-1987_12
Patent number
US04710507

Reaction notes

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