化工社化工社 化学情報印刷レポート · 研究参考用
Sulfuric Acid → 6-Bromo-8-methylquinolin-2(1H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide | HCID 14221021 | — |
| 生成物 | 6-Bromo-8-methylquinolin-2(1H)-one | HCID 13836183 | — |
反応手順
Trans-N-(4-bromo-2-methylphenyl)-3-ethoxypropenamide (2.0 g) was added portionwise with stirring to 98% sulphuric acid (15 cm3) at room temperature. After 16 hours the solution was poured onto ice (100 cm3) and the resulting precipitate was filtered off and dried (1.5 g). Recrystallisation from ethyl acetate-methanol afforded 6-bromo-8-methyl-2-(1H)-quinolone, m.p. 272°-274°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04710507 |
| 出典データセット | uspto-grants-1987_12 |
| ORD ID | ord-674e5d882af34c6c89ad6680d541a1e5 |
| 出典メモ | uspto-grants-1987_12 |