HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-methylaniline → N-(4-bromo-2-methylphenyl)-3-oxobutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-methylaniline | HCID 11423 | — |
| Reactant | Diketene | HCID 12661 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(4-bromo-2-methylphenyl)-3-oxobutanamide | HCID 4100579 | — |
Reaction Steps
A mixture of 4-bromo-2-methylaniline (25 g) and diketene (11.8 cm3) in toluene (100 cm3) was heated with stirring under reflux for 5 hours. On cooling to room temperature the precipitated solid was filtered off and recrystallised from hexane/ethyl acetate to afford N-[4-bromo-2-methylphenyl]-acetoacetamide, m.p. 109° (14.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04710507 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-4d8422dc2bed486d8ed9e4a7451c3bc9 |
| Source note | uspto-grants-1987_12 |