反应详情

Manganese dioxide (0.044 g) was added to a stirred solution of 2-amino-5-iodobenzyl alcohol (0.125 g) in dichloromethane (10 cm3) and the mixture was stirred for 6 hours. A further portion of manganese dioxide (0.044 g) was then added and stirring was continued for 16 hours. The mixture was then filtered, the filtrate evaporated in vacuo, and the residue chromatographed on silica (Merck "MK 60.9385") eluting with ethyl acetate. The requisite fractions were combined and concentrated in vacuo to afford 2-amino-5-iodobenzaldehyde. 0.5H2O as a solid, m.p. 105°, (0.1 g).

1. stirringstirring
2. waitwas continued for 16 hours
3. filtrationThe mixture was then filtered
4. customthe filtrate evaporated in vacuo
5. customthe residue chromatographed on silica (Merck "MK 60.9385")
6. washeluting with ethyl acetate
7. concentrationconcentrated in vacuo