Acetic Anhydride → HCID 178437299, compound

HRID 986044Notes

Reaction equation

HRID 986044 reaction equation
Cl.[CH2:2]([CH:4]1[C:24]2[C:7](=[CH:8][C:9]3[NH:13][C:12]([C:14]4[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][C:15]=4[O:21][CH3:22])=[N:11][C:10]=3[CH:23]=2)[NH:6][C:5]1=[O:25])[CH3:3].[C:26](OC(=O)C)(=[O:28])[CH3:27].C([O-])(=O)C.[Na+]>>[CH2:2]([CH:4]1[C:24]2[C:7](=[CH:8][C:9]3[NH:13][C:12]([C:14]4[CH:19]=[CH:18][C:17]([NH:20][C:26](=[O:28])[CH3:27])=[CH:16][C:15]=4[O:21][CH3:22])=[N:11][C:10]=3[CH:23]=2)[NH:6][C:5]1=[O:25])[CH3:3]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 517045Sodium AcetateHCID 178437298HCID 178437298, compound

Product 1

HCID 178437299HCID 178437299, compound

Procedure

0.7 g. (1.8 mmol) 7-ethyl-2-(2-methoxy-4-aminophenyl)-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-one hydrochloride, 15 ml. acetic anhydride and 0.3 g. sodium acetate were stirred for 3 hours at 40° C. After cooling, the product was filtered off with suction and, after treatment with charcoal, crystallised from methanol. There was obtained 0.44 g. (69% of theory) of the title compound; m.p. 245°-249° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe product was filtered off with suction
  3. customafter treatment with charcoal, crystallised from methanol
  4. customThere was obtained 0.44 g

Sources & evidence

ORD record
ord-f5a750a1c2d24110b0ece384c952e581
Source dataset
uspto-grants-1987_12
Patent number
US04710510

Reaction notes

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