HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline → 2-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline | HCID 333189 | — |
| Reactant | 2-(2,4-Dichloro-6-methoxyphenyl)-4,4-dimethyl-2-oxazoline | HCID 12802883 | — |
| Reactant | HCID 178418676 | HCID 178418676 | — |
| Reactant | HCID 178489560 | HCID 178489560 | — |
| Product | 2-(3,5-Dichloro-4'-fluoro-2-[1,1'-biphenyl]yl)-4,4-dimethyl-2-oxazoline | HCID 12802884 | — |
Reaction Steps
By substituting equimolar amounts of 2-(2,4-dichloro-6-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 4-fluorophenylmagnesium bromide for 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline and 2-methoxyphenylmagnesium bromide, the title compound was prepared following the procedure of Example 17, Step A, (85%), mp 93°-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04710513 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-f8a353aafcc1481e86df9107b4a806d0 |
| Source note | uspto-grants-1987_12 |