HCID 20129999, compound → 4-(6'-Methyloctyloxy)phenol

HRID 986100Notes

Reaction equation

HRID 986100 reaction equation
[CH3:1][CH:2]([CH2:23][CH3:24])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15]CC2C=CC=CC=2)=[CH:11][CH:10]=1.[H][H]>[Pd].C(O)C>[CH3:1][CH:2]([CH2:23][CH3:24])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 20129999HCID 20129999, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 230392144-(6'-Methyloctyloxy)phenol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A flask was charged with 23.37 g of optically active 4-benzyloxyphenyl 6-methyloctyl ether, 2.33 g of 10% Pd/C and 230 ml of ethanol, and the mixture was reacted at room temperature until it reacted with a theoretical amount of hydrogen. After completion of the reaction, the catalyst was removed by filtration and the organic solvent was distilled under reduced pressure to obtain a crude product. The crude product was refined to obtain 16.91 g of the intended phenol.

Workup

  1. customthe mixture was reacted at room temperature until it
  2. customAfter completion of the reaction
  3. customthe catalyst was removed by filtration
  4. distillationthe organic solvent was distilled under reduced pressure
  5. customto obtain a crude product

Sources & evidence

ORD record
ord-96078e6c270b4c04a211f99215ea7dc6
Source dataset
uspto-grants-1987_12
Patent number
US04710585

Reaction notes

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