Sodium Bicarbonate → HCID 70401798, compound

Participants

Reaction Conditions

Reaction Steps

To 30 ml of acetone was dissolved 1.17 g (1.8 mmole) of 2-(acetoacetyloxy)-3-(octadecyloxy)propyl 5-(pyrrolidino)pentyl phosphate, and 820 mg (10 mmole) of sodium hydrogen-carbonate previously crushed in a mortar and 410 mg (2.2 mmole) of methyl para-tolanesulrte were added to the solution. The mixture was stirred at 50° C. for 13 hours and acetone was distilled off under reduced pressure. In 30 ml of water was dissolved the residue and the solution was adjusted to pH 4 with 2N HCl, followed by extraction with a mixture of dichloromethane and ethanol (10:1). The solvent was distilled off and the residue was purified by silica gel column chromatography [chloroform-methanol-water (65:25:4)] to give 550 mg yield: 46%) of the desired compound.

Provenance & Evidence