Lithium hydride → HCID 12121236, compound

Participants

Reaction Steps

Acid (2) (12 g) was dissolved in ether (distilled from sodium/potassium) and treated with lithium hydride (1.27 g) in a nitrogen atmosphere. When reaction was complete the excess lithium aluminium hydride was destroyed using ethyl acetate and then water. The organic phases were separated and the aqueous phase washed with ether (2×20 ml). The organic phases were combined and dried (MgSO4) and after filtration the solvent was removed on the rotary evaporator 4. The red oil resulting had two components. Column chromatography (30 cm×2 cm) on silica eluted with 1:1 ether:hexane gave the alcohol and an ester.

Provenance & Evidence