1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 70436506, compound

Participants

Reaction Steps

Over a period of 20 minutes 29 g of ethyl 4-bromocrotonate are added to 69 g of 1-(3-trifluoromethylphenyl)-piperazine dissolved in 300 ml of anhydrous toluene. The mixture is then heated at reflux for 1 hour. After cooling, the hydrobromide is filtered with suction and the filtrate is concentrate to dryness in vacuo. In this manner crude 4-(3-trifluoromethylphenyl)piperazin-1-ylbut-2-enoic acid ethyl ester is obtained in theoretical yield.

Provenance & Evidence