HCID 70436506, compound → HCID 70437338, compound

HRID 986209Notes

Reaction equation

HRID 986209 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[C:5]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH2:10][CH2:9]1)=[CH:6][CH3:7])[CH3:2]>C(O)C.[Ni]>[CH2:1]([O:3][C:4](=[O:24])[CH:5]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:22])([F:21])[F:23])[CH:15]=2)[CH2:10][CH2:9]1)[CH2:6][CH3:7])[CH3:2]

Participants

4

Reactant 1

HCID 70436506HCID 70436506, compound

Product 1

HCID 70437338HCID 70437338, compoundYield 134%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

23 g of this ester dissolved in 200 ml of ethanol are hydrogenated under 60 lbs of pressure in the presence of Raney nickel. The theoretical quantity of hydrogen is absorbed in 3 hours. After filtration of the catalyst, the filtrate is concentrated in vacuo and the residue is distilled. In this manner 31 g of 4-(3-trifluoromethylphenyl)piperazin-1-ylbutanoic acid ethyl ester are obtained, b.p.0.3 mm Hg =146°-147° C.

Workup

  1. customThe theoretical quantity of hydrogen is absorbed in 3 hours
  2. filtrationAfter filtration of the catalyst
  3. concentrationthe filtrate is concentrated in vacuo
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-5a33ea1cc17646759a6972e8fc538bb6
Source dataset
uspto-grants-1987_12
Patent number
US04711885

Reaction notes

Loading…