HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl alpha-oxobenzenebutanoate → (+/-)-Dihydro-3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-4-oxo-1,5-benzothiazepine-5(2H)acetic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl alpha-oxobenzenebutanoate | HCID 562087 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (+/-)-3-amino-3,4-dihydro-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester | HCID 15591257 | — |
| Product | (+/-)-Dihydro-3-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-4-oxo-1,5-benzothiazepine-5(2H)acetic acid, ethyl ester | HCID 86741917 | — |
Reaction Steps
(±)-3-Amino-3,4-dihydro-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester is reacted with ethyl-2-oxo-4-phenylbutyrate in the presence of sodium cyanoborohydride according to the procedure of Example 1(f) to yield (±)-dihydro-3-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-4-oxo-1,5-benzothiazepine-5(2H)-acetic acid, ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04711884 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-01e3a3ad61c2474ba4cf7386aa6e1ebe |
| Source note | uspto-grants-1987_12 |