反应详情

Methyl 2-phenyl-4-quinolone-6-carboxylate (3.8 grams) obtained in Example 1 is refluxed for three hours in a mixture of 100 ml of methanol, 3 grams of sodium hydroxide and 15 ml of water. The mixture is evaporated to dryness in vacuo, 100 ml of water is added to the residue, filtered, acidified with 10% hydrochloric acid solution, and the crystals which separate out therefrom are collected by filtration. These are recrystallized from dimethyl formamide to give 2.8 grams of 2-phenyl-4-quinolone-6-carboxylic acid, colorless powder, melting at above 300° C.

1. customThe mixture is evaporated to dryness in vacuo, 100 ml of water
2. additionis added to the residue
3. filtrationfiltered
4. customthe crystals which separate out
5. filtrationtherefrom are collected by filtration
6. customThese are recrystallized from dimethyl formamide