Ethanol → Ethyl 2-phenyl-4-quinolone-6-carboxylate

HRID 986238Notes

Reaction equation

[C:1]1([C:7]2[CH2:16][C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:18]([OH:20])=[O:19])[CH:13]=3)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[CH2:22](O)[CH3:23]>S(=O)(=O)(O)O>[C:1]1([C:7]2[CH2:16][C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:18]([O:20][CH2:22][CH3:23])=[O:19])[CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Conditions

Temperature: 80 °C

Procedure

2-Phenyl-4-quinolone-6-carboxylic acid (1.3 grams) obtained in Example 2 is dissolved in 80 ml of ethanol and 0.5 ml of concentrated sulfuric acid. The solution is stirred for three days at 80° C., water is added thereto, crystals which separate out therefrom are collected by filtration. These are washed with water and dried to give 1.4 grams of ethyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting at above 300° C.

Workup

customcrystals which separate out
filtrationtherefrom are collected by filtration
washThese are washed with water
customdried

Sources & evidence

ORD record: ord-99f75ea0dd5d436c84a40ad538dc54ad
Source dataset: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04711898

Reaction notes

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