反应详情

2-Phenyl-4-quinolone-6-carboxylic acid (1.5 grams) obtained in Example 2 is stirred for fifteen hours at 110° C. with 50 ml of phenethyl alcohol and 1 ml of concentrated sulfuric acid. After cooling, 1.5 liters of ether is added to the mixture, the mixture is cooled with ice, oil which separates out therefrom is taken out. The mixture is then dissolved in 5 ml of ethanol. Then 3 ml of water is added thereto, and crystal which separates out therefrom are collected by filtration, and washed with a 5% sodium bicarbonate solution, then with water, and finally with methanol, and dried to give 0.9 gram of phenethyl 2-phenyl-4-quinolone-6-carboxylate, colorless powder, melting point 282°to 284° C.

1. temperatureAfter cooling
2. temperaturethe mixture is cooled with ice, oil which
3. filtrationout therefrom are collected by filtration
4. washwashed with a 5% sodium bicarbonate solution
5. dry with materialwith water, and finally with methanol, and dried