Water → 1-Methyl-4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylic acid

HRID 986242Notes

Reaction equation

[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14]C)=[O:13])=[CH:9][CH:10]=2)[C:5](=[O:16])[CH:4]=[C:3]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[Na+].O>C(O)(=O)C>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([OH:14])=[O:13])=[CH:9][CH:10]=2)[C:5](=[O:16])[CH:4]=[C:3]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Conditions

Temperature: 60 °C

Procedure

To 0.9 gram of methyl 1-methyl-2-phenyl-4-quinolone-6-carboxylate obtained in Example 7 are added 0.5 gram of sodium hydroxide and 40 ml of water and the mixture is stirred at 60° C. for two hours. The mixture is acidified with acetic acid, and crystals which separate out therefrom are collected by filtration, and dried to give 0.5 gram of 1-methyl-2-phenyl-4-quinolone-6-carboxylic acid, colorless powder, melting at above 30° C.

Workup

customseparate out
filtrationtherefrom are collected by filtration
customdried

Sources & evidence

ORD record: ord-5bdc9bcdca2347428a3edf007cc991eb
Source dataset: uspto-grants-1987_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04711898

Reaction notes

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