Hydrochloric Acid → HCID 70433153, compound

Participants

Reaction Steps

The compound of example 57 was prepared in the following manner: to 4 grams of 6-cyano-2-(2-methoxyphenyl)-4-quinolone were added 3 grams of potassium hydroxide and 100 ml. of methanol, the mixture was heated to reflux for 4 hours, then poured into ice water. The mixture was adjusted to pH 3 with 10% hydrochloric acid, and crystals which separate out therefrom were collected by filtration and recrystallized from dimethyl formamide to give 2.7 grams of the desired 2-(2-methoxyphenyl)-4-quinolone-6-carboxylic acid, colorless crystals, melting point 290° to 294° C.

Provenance & Evidence