p-Toluenesulfonic acid → HCID 70432956, compound

Participants

Reaction Steps

A mixture of 7 grams of ethyl benzoylacetate, 6 grams of ethyl anthranilate and 0.5 gram of p-toluenesulfonic acid is dehydrated (by heating) in 300 ml of benzene for three days. Benzene is evaporated therefrom, and the resulting oil is heated at 250° to 280° C. for 0.5 hour in 20 ml of diphenyl ether. After cooling, 250 ml of n-hexane is added thereto, and crystals which separate out therefrom are collected by filtration and recrystallized from methanol to give 4.2 grams of ethyl 2-phenyl-4-quinolone-8-carboxylate, pale brown needles, melting point 218° to 219° C.

Provenance & Evidence