Ethylene Glycol → HCID 70433510, compound

HRID 986248Notes

Reaction equation

HRID 986248 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH2:17][C:16](=[O:18])[C:15]2[C:10](=[C:11]([C:19]([OH:21])=[O:20])[CH:12]=[CH:13][CH:14]=2)[N:9]=1.O.[CH2:23](O)[CH2:24][OH:25]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH2:17][C:16](=[O:18])[C:15]2[C:10](=[C:11]([C:19]([O:21][CH2:23][CH2:24][OH:25])=[O:20])[CH:12]=[CH:13][CH:14]=2)[N:9]=1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 962WaterHCID 704331432-(2-Chlorophenyl)-4-quinolone-8-carboxylic acid

Product 1

HCID 70433510HCID 70433510, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

2-(2-Chlorophenyl)-4-quinolone-8-carboxylic acid (10 grams) was stirred overnight at 95° to 98° C. in a mixture of 10 ml of concentrated sulfuric acid and 100 ml of ethylene glycol. The reaction solution was poured over into water and separated crystals were collected by filtration and then washed with water. After dried, the crystals were re-crystallized from acetone to give 8.2 grams of the title compounds, pale yellow prisms, melting point 170° to 171° C.

Workup

  1. customseparated crystals
  2. filtrationwere collected by filtration
  3. washwashed with water
  4. customAfter dried
  5. customthe crystals were re-crystallized from acetone

Sources & evidence

ORD record
ord-db357dde3362485489a754010396f5fb
Source dataset
uspto-grants-1987_12
Patent number
US04711898

Reaction notes

Loading…