反应详情

2-(2-Chlorophenyl)-4-quinolone-8-carboxylic acid (10 grams) was stirred overnight at 95° to 98° C. in a mixture of 10 ml of concentrated sulfuric acid and 100 ml of ethylene glycol. The reaction solution was poured over into water and separated crystals were collected by filtration and then washed with water. After dried, the crystals were re-crystallized from acetone to give 8.2 grams of the title compounds, pale yellow prisms, melting point 170° to 171° C.

1. customseparated crystals
2. filtrationwere collected by filtration
3. washwashed with water
4. customAfter dried
5. customthe crystals were re-crystallized from acetone