反应详情

A mixture of 4.5 g of 9-acridanone, 1.1 g of sodium hydride and 100 ml of dimethylformamide is stirred for 0.5 hour, then treated with 5.2 g of 2-(4-acetyl-1-piperazinyl)-ethyl chloride hydrochloride, stirred at 70° for 15 hours and evaporated. The residue is treated with water and extracted with methylene chloride. The extract is washed with water, dried over sodium sulfate and evaporated. By crystallization from ethanol there is obtained 10-[2-(4-acetyl-1-piperazinyl)ethyl]-9-acridanone of melting point 241°-243°.

1. stirringstirred at 70° for 15 hours
2. customevaporated
3. additionThe residue is treated with water
4. extractionextracted with methylene chloride
5. washThe extract is washed with water
6. dry with materialdried over sodium sulfate
7. customevaporated
8. customBy crystallization from ethanol