Hydrogen Bromide → HCID 20158335, compound

Participants

Reaction Steps

A suspension of 11.2 g of benzyl [2-(9-oxo-10(9H)-acridinyl)ehtyl]carbamate in 100 ml of glacial acetic acid is treated with 20 ml of hydrogen bromide-containing glacial acetic acid (about 30 percent) and stirred for 1 hour. The product is filtered and washed with glacial acetic acid and ether. There is obtained 10-(2-aminoethyl)-9-acridanone hydrobromide of melting point >250°. The free base is precipitated from an aqueous solution with sodium bicarbonate solution, filtered and washed with water and acetone. The hydrochloride obtained therefrom and analyzed melts above 250°.

Provenance & Evidence