N-Methylcyclohexylamine → N-cyclohexyl-N-methyl-2-phenylquinoline-4-carboxamide

HRID 986285Notes

Reaction equation

HRID 986285 reaction equation
Cl.[C:2]1([C:8]2[CH:17]=[C:16]([C:18](Cl)=[O:19])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:21][NH:22][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>C(Cl)Cl>[CH:23]1([N:22]([CH3:21])[C:18]([C:16]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:17]=2)=[O:19])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 7514N-MethylcyclohexylamineHCID 123740002-Phenylquinoline-4-carbonyl chloride hydrochloride

Product 1

HCID 13336357N-cyclohexyl-N-methyl-2-phenylquinoline-4-carboxamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The procedure of Example 41 is followed using 2-phenylquinoline-4-carboxylic acid chloride hydrochloride (9.1 g) and N-methylcyclohexylamine (13.5 g) in methylene chloride (100 ml) as the starting materials.

Sources & evidence

ORD record
ord-1a5989a9d492490a8ec6c3e42adab907
Source dataset
uspto-grants-1987_12
Patent number
US04711890

Reaction notes

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