Hydrochloric Acid → HCID 13772581, compound

Participants

Reaction Steps

In a manner analogous to that described in Stage 15.4, from 3.24 g (6.7 mmol) of N-benzyloxycarbonyl-L-alanine-3-[2-(4-isobutylphenyl)-propionylamino]-2-hydroxypropylamide by means of catalytic hydrogenation [1 g of palladium-on-carbon (10% palladium), 15 minutes, room temperature, normal pressure] in methanol at pH 7 (titration with 1N hydrochloric acid), there is obtained L-alanine-3-[2-(4-isobutylphenyl)propionylamino]-2-hydroxypropylamide hydrochloride in the form of colourless crystals which decompose at 88° and above (triturated with diethyl ether) and contain 0.43 mol of water; [α]D20 =+8.3°±0.9° (c=1.065; methanol), Rf =0.30 (chloroform:methanol=4:1), Rf =0.58 (chloroform:methanol:water=70:30:5).

Provenance & Evidence