Chloroform → 1-Isopropyl-3,3,5,5-tetramethyl-2-piperazinone

Participants

Reaction Steps

In a 1 liter flask cooled in an ice-bath, put 1 g mol of N1 -isopropyl-2-methyl-1,2-propanediamine, 1.25 g mols of chloroform, and, 1.25 g mols of acetone. Add about 5% by wt tributylamine as the phase transfer catalyst, and slowly drip into the flask about 3 g mols of 50% aqueous NaOH solution, while stirring. Upon working up the reaction product in a conventional manner, a reaction product is obtained which is predominantly the compound represented by the structural formula immediately hereinabove. A minor amount of N1 -isopropyl-3,3,6,6-tetramethyl-piperazin-2-one is also recovered.

Provenance & Evidence