HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2RS, 3S)-3-(tert-butoxycarbonyl)amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide | HCID 86741924 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide hydrochloride | HCID 14181682 | — |
Reaction Steps
To a solution of 590 mg of the amide compound in 10 ml of methyl alcohol was added 3.3 ml of a 2N-hydrochloric acid, and the mixture was heated under reflux for 2 hours. The reaction mixture was evaporated under reduced pressure to obtain 254 mg of (2RS, 3S)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutylbutyramide hydrochloride as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04711958 |
| Source dataset | uspto-grants-1987_12 |
| ORD ID | ord-e69f516287d149bd99aca742b55ea53e |
| Source note | uspto-grants-1987_12 |