Isobutylamine → HCID 20157325, compound

Participants

Reaction Steps

The product of step (d) (1 g, 2.8 mmol) was treated with triethylamine (0.66 mL, 4.8 mmol) and phenyl N-phenylphosphoroamidochloridate (1 g, 3.8 mmol) in dry dichloromethane for 30 mins under nitrogen at room temperature. Isobutylamine (0.66 mL, 6.6 mmol) and triethylamine (0.66 mL, 4.8 mmol) were added and after 24 hours the reaction mixture was subjected to standard work-up procedures. The crude product was purified by column chromatography (1:1 hexane:ether, silica) to give 0.57 g (50% of theory) of N-isobutyl 11-(3'trifluoromethylbenzyloxy)-(2E,4E)-undecadienamide. mp 48°-50°.

Provenance & Evidence